6 Ways How CBD Interacts with Medications

A drug interaction is a response that occurs when a medicine is taken in conjunction with food, beverage, or supplements. It may also refer to a response that occurs when two or more medicines are combined. When you take medicine while experiencing a certain medical condition, it is also likely to have a drug interaction. For example, you may want to use a nasal decongestant to relieve the congestion when you have hypertension.

As a part of this post, we’ll take a look at various frequently used medication kinds and examine their possible interactions with CBD.

Antidepressants are number one on the list.


According to the Centers for Disease Control and Prevention, over 12 percent of Americans aged 12 and up had taken an antidepressant in the previous month, with fluoxetine (Prozac and Sarafem) being the most frequently prescribed. CBD is often used to treat depression, and it is not uncommon for patients to combine CBD with antidepressants such as Prozac in an effort to fight the blues.

Bulimia, obsessive-compulsive disorder (OCD), and anxiety are all treated with fluoxetine, which is a selective serotonin reuptake inhibitor. Sweating, diarrhea, strange nightmares, and a rash on the skin are all common adverse effects of this medication. According to experts, selective serotonin reuptake inhibitors (SSRIs) operate by increasing the levels of neurotransmitters in the brain, such as serotonin and dopamine.

Blood Thinners are number two on the list.

CBD, along with other cannabinoids found in plants, can enhance the effects of blood-thinning medications such as warfarin and medicines that thin the blood, such as ibuprofen. Research by Grayson et al., published in Epilepsy & Behavior Case Reports in October 2017, showed that warfarin and cannabidiol (CBD) interact.

Drugs for the treatment of epilepsy and seizures


According to CBD proponents, one of the benefits of CBD Edibles is that it does not provide an intoxicating high. Therefore, a growing number of parents are comfortable with using cannabidiol to treat their children’s epilepsy symptoms.While recent research indicates that large doses of CBD may be effective in treating the symptoms of epilepsy, Lester Bornheim discovered something intriguing back in 1992 that deserves to be shared. It turns out that a modest dosage of CBD has no antiepileptic effect, but it does have an inhibitory impact on the CYP450 enzymes. As a consequence, antiepileptic medications such as nor clobazam and clobazam are kept in the bloodstream for longer periods causing more violent seizures.


Anti-influenza and cold medications

cold medications

There have also been reports of pharmacological interactions between CBD and over-the-counter cold and flu medications (OTC). Here is a short summary of the ingredients found in different cold and flu medications that have the potential to cause adverse effects when used with CBD:

  • Doxylamine: Found in antihistamines such as Nyquil, this antihistamine has the potential to enhance the relaxing or sleepy effects of CBD.
  • It is possible that the anti-inflammatory drug naproxen, which is included in products such as Aleve, may decrease the efficacy of CBD.

Antiretroviral drugs are number five on the list.

Antiretroviral drugs

Globally, approximately 40 million individuals are infected with HIV/AIDS, according to estimates. As a result of HIV’s effect on the immune system, patients are more susceptible to infection. Anxiety and discomfort are two symptoms that CBD users claim they may alleviate. CBD users think it can help strengthen their immune function and offer relief for these symptoms. HIV/AIDS is now treated with antiretroviral medicines such as Saquinavir and Ritonavir, which are both available over the counter.

Anti-anxiety medications are number six on the list

CBD Interaction

A well-known risk of combining an anti-anxiety drug such as Xanax with opioids and alcohol is that it may cause death. However, we don’t have enough data that clearly describes what occurs when CBD is combined with a psychoactive substance like LSD. Because of CBD’s impact on the CYP450 system, you will most likely have a higher than normal amount of the substance in your blood. The likelihood of experiencing side effects such as disorientation, lack of concentration, and sleepiness is high.


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One thought on “6 Ways How CBD Interacts with Medications

  1. Using cannabis with drugs like citalopram can give you a fast heartbeat and make drowsiness worse.

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